SYNTHESIS AND CYTOTOXIC PROPERTY OF ANNONACEOUS ACETOGENIN GLYCOCONJUGATES

Jing-Fang Shi,1,2 Ping Wu,2 Xiao-Li Cheng,2 Xiao-Yi Wei,2 Zi-Hua Jiang3 1Guangdong Provincial Key Laboratory for Crop Germplasm Resources Preservation and Utilization, Agro-Biological Gene Research Center, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, People’s Republic of China; 2Key Laboratory of Plant Resources Conservation

Introduction Hypercholesterolemia is a primary element leading to the occurrence of cardiovascular diseases, which are the most common cause of death worldwide.One of the most effective drugs used in the treatment of hypercholesterolemia are statins.Monacolin K is a naturally derived substance that exhibits similar effects.Materials and methods The